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  • Publications (1991-2009) - Novembre 2011

    PUBLICATION 1991 Van Vooren JP, Drowart A, De Cock M, Van Onckelen A, D’Hoop MH, Yernault JC, Valcke C, Huygen K. Humoral immune response of tuberculous patients against the three components of the Mycobacterium bovis BCG 85 complex separated by isoelectric focusing. J Clin Microbiol. 29,2348-50,1991. PUBLICATIONS 1992 Drowart A, De Bruyn J, Huygen K, Damiani G, Godfrey HP, Stélandre M, Yernault JC, Van Vooren JP. Isoelectrophoretic characterization of protein antigens present in (...)

  • Publications 1991 - Juillet 2011

    Van Vooren JP, Drowart A, De Cock M, Van Onckelen A, D’Hoop MH, Yernault JC, Valcke C, Huygen K. Humoral immune response of tuberculous patients against the three components of the Mycobacterium bovis BCG 85 complex separated by isoelectric focusing. J Clin Microbiol. 29,2348-50,1991

  • Publications 1992 - Juillet 2011

    Drowart A, De Bruyn J, Huygen K, Damiani G, Godfrey HP, Stélandre M, Yernault JC, Van Vooren JP. Isoelectrophoretic characterization of protein antigens present in mycobacterial culture filtrates and recognized by monoclonal antibodies directed against the Mycobacterium bovis BCG antigen 85 complex. Scand J Immunol. 36,697-702,1992.
    Stélandre, M. Bosseloir Y, De Bruyn J, Maes P, Content J. Cloning and sequence analysis of the gene encoding an NADP-dependent alcohol dehydro­genase in (...)

  • Publications 1993 - Juillet 2011

    Fontaine V, Savino R, Arcone R, de Wit L, Brakenhoff JP, Content J, Ciliberto G. Involvement of the Arg179 in the active site of human IL-6. Eur J Biochem. 211,749-55,1993.

  • Publications 1994 - Juillet 2011

    Braibant M, De Wit L, Peirs P, Kalai M, Ooms J, Drowart A, Huygen K, Content J. Structure of the Mycobacterium tuberculosis antigen 88, a protein related to the Escherichia coli PstA periplasmic phosphate permease subunit. Infect Immun. 62,849-54,1994. Brakenhoff JP, de Hon FD, Fontaine V, ten Boekel E, Schooltink H, Rose-John S, Heinrich PC, Content J, Aarden LA. Development of a human interleukin-6 receptor antagonist. J Biol Chem. 269, 86-93,1994. Fontaine V, Ooms J, Content J. (...)

  • Publications 1995 - Septembre 2009

    Hendrix C, Mahieu M, Anné J, Van Calenbergh S, Van Aerschot A, Content J, Herdewijn P. Catalytic activity and stability of hammerhead ribozymes containing 2’-acetamido-2’-deoxyribonucleosides. Biochem Biophys Res Commun. 210,67-73,1995 Mahieu M, Hendrix C, Ooms J, Herdewijn P, Content J. In vitro NCp7 enhancement of ribozyme-mediated cleavage of full-length human IL-6 mRNA. Biochem Biophys Res Commun. 214,36-43,1995. Snyers L, Renauld JC, Szpirer C, Content J. Cloning and chromosomal (...)

  • Publications 1996 - Septembre 2009

    Braibant M, Lefèvre P, de Wit L, Ooms J, Peirs P, Huygen K, Wattiez R, Content J. Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter. FEBS Lett. 394,206-12,1996. Braibant M, Lefèvre P, de Wit L, Peirs P, Ooms J, Huygen K, Andersen AB, Content J. A Mycobacterium tuberculosis gene cluster encoding proteins of a phosphate transporter homologous to the Escherichia coli Pst system. Gene 176,171-6,1996. Huygen K, Content J, (...)

  • Publications 1997 - Septembre 2009

    Denis O, Lozes E, Huygen K. Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guérin-infected mice. Infect Immun. 65,676-84,1997. Lozes E, Denis O, Drowart A, Jurion F, Palfliet K, Vanonckelen A, De Bruyn J, De Cock M, Van Vooren JP, Huygen K. Cross-reactive immune responses against Mycobacterium bovis BCG in mice infected with non-tuberculous mycobacteria belonging to the MAIS-Group. Scand J Immunol.46,16-26,1997. O. (...)

  • Publications 1998 - Septembre 2009

    Y. Jacques, S. Minvielle, G. Muller-Newen, P.C. Heinrich, J. Grotzinger, F. Montero-Julian, H. Brailly, J.M. Wilkin, and J. Content, The interleukin-11/receptor complex : rational design of agonists/antagonists and immunoassays potentially useful in human therapy, Res. Immunol. 149:737-740 (1998).
    Denis O, Tanghe A, Palfliet K, Jurion F, van den Berg TP, Vanonckelen A, Ooms J, Saman E, Ulmer JB, Content J, Huygen K. Vaccination with plasmid DNA encoding mycobacterial antigen 85A (...)

  • Publications 1999 - Septembre 2009

    A. Tanghe, P. Lefevre, O. Denis, S. D’Souza, M. Braibant, E. Lozes, M. Singh, D. Montgomery, J. Content, and K. Huygen, Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors. J Immunol 162,1113‑1119,1999. Vercammen, M, T. Scorza, A. Elbouhdidi, K. Vanbeeck, Y. Car­lier, J.F. Dubremetz, and H. Verschueren, Opsonization of Toxoplasma gondii tachyzoites with nonspecific immunoglobulins promotes their phagocytosis by macrophages (...)

  • Publications 2000 - Septembre 2009

    D’Souza, S, O. Denis, T. Scorza, F. Nzabintwali, H. Verschueren, and K. Huygen. CD4(+) T cells contain Mycobacte­rium tuberculosis infection in the absence of CD8(+) T cells in mice vaccinated with DNA encoding Ag85A. Eur. J. Immunol. 30,2455‑2459,2000. Turner, O.C., A.D. Roberts, A.A. Frank, S.W. Phalen, D.M. Mcmurray, J. Content, O. Denis, S. D’Souza, A. Tanghe, K. Huygen, and I.M. Orme. Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea (...)

  • Publications 2001 - Juillet 2011

    Galamba A, Soetaert K, Wang XM, De Bruyn J, Jacobs P, Content J. Disruption of adhC reveals a large duplication in the Mycobac­terium smegmatis mc(2)155 genome. Microbio­logy 147,328­1‑94,2001. Galamba A, Soetaert K, Buyssens P, Monnaie D, Jacobs P, Con­tent J. Molecular and biochemical characterisation of Mycobac­terium smegma­tis alcohol dehydrogenase C. FEMS Microbiol Lett 196,51‑6, 2001. Y. Fikri, O. Denis, P.-P. Pastoret and J. Nyabenda. Purified bovine WC1+ T lymphocytes are activated by (...)

  • Publications 2002 - Juillet 2011

    Wang XM, Wilkin JM, Bois­teau O, Harmegnies D, Blanc C, Vanden­bus­sche P, Monte­ro‑Julian FA, Jacques Y, Content J. Engineering and use of 32P‑labeled human recombinant interleu­kin‑11 for receptor binding studies. Eur J Biochem 269,61‑8,2002. Fikri Y, Pastoret PP, Nyabenda J. Costimulatory molecule requirement for bovine WC1+gammadelta T cells’ proliferative response to bacterial superantigens. Scand J Immunol. 55,373-81,2002. Walravens K, Marche S, Rosseels V, Wellemans V, Boelaert F, Huygen (...)

  • Publications 2003 - Juillet 2011

    Harmegnies D, Wang XM, Vandenbussche P, Leon A, Vusio P, Grötzinger J, Jacques Y, Goormaghtigh E, Devreese B, Content J. Characterization of a potent human interleukin-11 agonist.Biochem J. 375,23-32,2003. D’Souza S, Rosseels V, Romano M, Tanghe A, Denis O, Jurion F, Castiglione N, Vanonckelen A, Palfliet K, Huygen K.Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis. Infect Immun. 71,483-93,2003. Scorza T, D’Souza (...)

  • Publications 2004 - Juillet 2011

    Romano M, Denis O, D’Souza S, Wang XM, Ottenhoff TH, Brulet JM, Huygen K, Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis. J Immunol. 172,6913-21,2004. Prevot G, Bourreau E, Pascalis H, Pradinaud R, Tanghe A, Huygen K, Launois P. Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease. Infect (...)

  • Publications 2005 - Juillet 2011

    Peirs P., Lefèvre P., Boarbi S., Wang X-M., Denis O., Braibant M., Pethe K., Locht C., Huygen K. and Content J. Mycobacterium tuberculosis disrupted in its genes encoding the phosphate binding proteins PstS1 and PstS2, is deficient in phosphate uptake and demonstrates reduced in vivo virulence. Infect. Immun. 73,1898-1902,2005. Zozio, T., Allix, C., Gunal, S., Saribas, Z., Alp, A., Durmaz, R., Fauville-Dufaux, M., Rastogi, N. and Sola, C. Genotyping of Mycobacterium tuberculosis clinical (...)

  • Publications 2006 - Juillet 2011

    Romano, M., Roupie, V., Hamard, M. and Huygen, K. Evaluation of the immunogenicity of pBudCE4.1 plasmids encoding mycolyl-transferase Ag85A and phosphate transport receptor PstS-3 from Mycobacterium tuberculosis. Vaccine 24,4640-4643,2006 Rosseels, V., Marché, S., Roupie, V. Govaerts, M.,Godfroid, J., Walravens, K. and Huygen K. Members of the 30-to 32-kilodalton mycolyl transferase family (Ag85) from culture filtrate of Mycobacterium avium subsp. Paratuberculosis are immunodominant (...)

  • Publications 2007 - Octobre 2009

    Tanghe, A., P.Y. Adnet, T. Gartner and K. Huygen. A booster vaccination with M. bovis BCG does not increase the protective effect of the vaccine against experimental Mycobacterium ulcerans infection in mice. Infect. Immun. 75,2642-2644,2007. Fikri, Y, Nyabenda, J, Content, J. and Huygen, K. 2007. Cloning, sequencing and cell surface expression pattern of bovine immunoreceptor NKG2D and adaptor molecules DAP10 and DAP12. Immunogenetics 95,653-659,2007. Durmaz R, Zozio T, Gunal S, Allix (...)

  • Publications 2008 - Octobre 2009

    Tanghe A, Dangy JP, Pluschke G, Huygen K. Improved Protective Efficacy of a Species-Specific DNA Vaccine Encoding Mycolyl-Transferase Ag85A from Mycobacterium ulcerans by Homologous Protein Boosting. PLoS Negl Trop Dis. 2,199,2008. Romano, M., Rindi, L., Korf, H., Bonanni, D., Adnet, P.Y., Jurion, F., Garzelli, C., and Huygen, K. 2008. Immunogenicity and protective efficacy of tuberculosis subunit vaccines expressing PPE44 (Rv2770c). Vaccine 26,6053-6063,2008. Gartner T., M. Romano, V. (...)

  • Publications 2009 - Octobre 2009

    Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA,Grooten J, Huygen K. Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice. J Clin Invest. 119,1626-37,2009. Jongert E, Roberts CW, Gargano N, Förster-Wald E, Petersen E.Vaccines against Toxoplasma gondii : challenges and opportunities. Mem Inst Oswaldo Cruz. 104,252-66,2009. Kijlstra A, Jongert E. Toxoplasma-safe meat : close to reality ? Trends Parasitol. (...)