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Publié : 25 juillet 2019

Publications depuis 2014


Kassem, A., Pays, E. and Vanhamme, L. (2014) ’Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei’, Proc Natl Acad Sci U S A, 111(24), pp. 8943-8.

Pyana Pati, P., Van Reet, N., Mumba Ngoyi, D., Ngay Lukusa, I., Karhemere Bin Shamamba, S. and Büscher, P. (2014) ’Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo’, PLoS Negl Trop Dis, 8(10), pp. e3212.


Kerkhof, K., Canier, L., Kim, S., Heng, S., Sochantha, T., Sovannaroth, S., Vigan-Womas, I., Coosemans, M., Sluydts, V., Ménard, D. and Durnez, L. (2015) ’Implementation and application of a multiplex assay to detect malaria-specific antibodies : a promising tool for assessing malaria transmission in Southeast Asian pre-elimination areas’, Malar J, 14, pp. 338.

Soetaert, K., Rens, C., Wang, X. M., De Bruyn, J., Lanéelle, M. A., Laval, F., Lemassu, A., Daffé, M., Bifani, P., Fontaine, V. and Lefèvre, P. (2015) ’Increased Vancomycin Susceptibility in Mycobacteria : a New Approach To Identify Synergistic Activity against Multidrug-Resistant Mycobacteria’, Antimicrob Agents Chemother, 59(8), pp. 5057-60.

Darcis, G., Kula, A., Bouchat, S., Fujinaga, K., Corazza, F., Ait-Ammar, A., Delacourt, N., Melard, A., Kabeya, K., Vanhulle, C., Van Driessche, B., Gatot, J. S., Cherrier, T., Pianowski, L. F., Gama, L., Schwartz, C., Vila, J., Burny, A., Clumeck, N., Moutschen, M., De Wit, S., Peterlin, B. M., Rouzioux, C., Rohr, O. and Van Lint, C. (2015) ’An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression’, PLoS Pathog, 11(7), pp. e1005063.


Birhanu, H., Gebrehiwot, T., Goddeeris, B. M., Büscher, P. and Van Reet, N. (2016) ’New Trypanosoma evansi Type B Isolates from Ethiopian Dromedary Camels’, PLoS Negl Trop Dis, 10(4), pp. e0004556.

Caljon, G., Van Reet, N., De Trez, C., Vermeersch, M., Pérez-Morga, D. and Van Den Abbeele, J. (2016) ’The Dermis as a Delivery Site of Trypanosoma brucei for Tsetse Flies’, PLoS Pathog, 12(7), pp. e1005744.

Fikru, R., Matetovici, I., Rogé, S., Merga, B., Goddeeris, B. M., Büscher, P. and Van Reet, N. (2016) ’Ribosomal DNA analysis of tsetse and non-tsetse transmitted Ethiopian Trypanosoma vivax strains in view of improved molecular diagnosis’, Vet Parasitol, 220, pp. 15-22.

Kerkhof, K. (2016) Serological markers to measure recent changes in malaria transmission - a promising tool towards malaria elimination. Ph. D. University of Antwerp, Antwerp, 204 pages

Kerkhof, K., Sluydts, V., Heng, S., Kim, S., Pareyn, M., Willen, L., Canier, L., Sovannaroth, S., Ménard, D., Sochantha, T., Coosemans, M. and Durnez, L. (2016) ’Geographical patterns of malaria transmission based on serological markers for falciparum and vivax malaria in Ratanakiri, Cambodia’, Malar J, 15(1), pp. 510.

Kerkhof, K., Sluydts, V., Willen, L., Kim, S., Canier, L., Heng, S., Tsuboi, T., Sochantha, T., Sovannaroth, S., Ménard, D., Coosemans, M. and Durnez, L. (2016) ’Serological markers to measure recent changes in malaria at population level in Cambodia’, Malar J, 15(1), pp. 529.

Bouchat, S., Delacourt, N., Kula, A., Darcis, G., Van Driessche, B., Corazza, F., Gatot, J. S., Melard, A., Vanhulle, C., Kabeya, K., Pardons, M., Avettand-Fenoel, V., Clumeck, N., De Wit, S., Rohr, O., Rouzioux, C. and Van Lint, C. (2016) ’Sequential treatment with 5-aza-2’-deoxycytidine and deacetylase inhibitors reactivates HIV-1’, EMBO Mol Med, 8(2), pp. 117-38.

Rens, C., Laval, F., Daffé, M., Denis, O., Frita, R., Baulard, A., Wattiez, R., Lefèvre, P. and Fontaine, V. (2016) ’Effects of Lipid-Lowering Drugs on Vancomycin Susceptibility of Mycobacteria’, Antimicrob Agents Chemother, 60(10), pp. 6193-9.


Darcis, G., Bouchat, S., Kula, A., Van Driessche, B., Delacourt, N., Vanhulle, C., Avettand-Fenoel, V., De Wit, S., Rohr, O., Rouzioux, C. and Van Lint, C. (2017) ’Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir’, AIDS, 31(2), pp. 181-189.

Fauquenoy, S., Robette, G., Kula, A., Vanhulle, C., Bouchat, S., Delacourt, N., Rodari, A., Marban, C., Schwartz, C., Burny, A., Rohr, O., Van Driessche, B. and Van Lint, C. (2017) ’Repression of Human T-lymphotropic virus type 1 Long Terminal Repeat sense transcription by Sp1 recruitment to novel Sp1 binding sites’, Sci Rep, 7, pp. 43221.

Gama, L., Abreu, C. M., Shirk, E. N., Price, S. L., Li, M., Laird, G. M., Pate, K. A., Wietgrefe, S. W., O’Connor, S. L., Pianowski, L., Haase, A. T., Van Lint, C., Siliciano, R. F., Clements, J. E. and the LRA-SIV Study Group. (2017) ’Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques’, AIDS, 31(1), pp. 5-14.


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Rens, C., Laval, F., Wattiez, R., Lefèvre, P., Dufrasne, F., Daffé, M. and Fontaine, V. (2018) ’I3-Ag85 effect on phthiodiolone dimycocerosate synthesis’, Tuberculosis, 108(Supplement C), pp. 93-95.

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Bannister-Tyrrell, M., Srun, S., Sluydts, V. Gryseels, C., Mean, V., Kim, S., Sokny, M., Peeters Grietens, M., Menard, D., Tho, S., Van Bortel, W. and Durnez, L. (2018) ’Importance of household-level risk factors in explaining micro-epidemiology of asymptomatic malaria infections in Ratanakiri Province, Cambodia ’, Sci Rep, 8, pp. 11643.

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Mylka, V., Deckers, J., Ratman, D., De Cauwer, L., Thommis, J., De Rycke, R., Impens, F., Libert, C., Tavernier, J., Vanden Berghe, W., Gevaert, K. and De Bosscher, K. (2018) The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages, Autophagy, 14(12):2049-2064. DOI : 10.1080/15548627.2018.1495681


Zeng S, Constant P, Yang D, Baulard A, Lefèvre P, Daffé M, Wattiez R and Fontaine V (2019). Cpn60.1 (GroEL1) Contributes to Mycobacterial Crabtree Effect : Implications for Biofilm Formation. Front. Microbiol. 10:1149. doi : 10.3389/fmicb.2019.01149

Verdikt R, Darcis G, Ait-Ammar A, Van Lint C. (2019) Applications of CRISPR/Cas9 tools in deciphering the mechanisms of HIV-1 persistence. Curr Opin Virol. 38:63-69

Zeng S, Soetaert K, Ravon F, Vandeput M, Bald D, Kauffmann J-M, Mathys V, Wattiez R, Fontaine V. 2019. Isoniazid bactericidal activity involves electron transport chain perturbation. Antimicrob Agents Chemother 63 : e01841-18. https://doi.org/10.1128/AAC.01841-18.

Kula A, Delacourt N, Bouchat S, Darcis G, Avettand-Fenoel V Verdikt R, Corazza F, Necsoi C, Vanhulle C, Bendoumou M, Burny A, De Wit S, Rouzioux C, Rohr O, Van Lint C. (2019) Heterogeneous HIV-1 Reactivation Patterns of Disulfiram and Combined Disulfiram+Romidepsin Treatments. J Acquir Immune Defic Syndr. 80 : 605-613.


Ait-Ammar A, Kula A, Darcis G, Verdikt R, De Wit S, Gautier V, Mallon PWG, Marcello A, Rohr O, Van Lint C. (2020) Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs. Front Microbiol. 10 : article 3060. doi : 10.3389/fmicb.2019.03060. eCollection 2019
Lange U, Verdikt R, Ait-Ammar A, Van Lint C. (2020) Epigenetic crosstalk in chronic infection with HIV-1. Semin Immunopathol. (2020) doi : 10.1007/s00281-020-00783-3.

Cuypers, B., Dumetz F., Meysman P. , Laukens, K., De Muylder G., Dujardin J-C. and Domagalska M A. (2020) “The Absence of C-5 DNA methylation in Leishmania donovani allows DNA enrichment from complex samples”. Microorganisms, 8, 1252 ; doi:10.3390/microorganisms8081252

Ouali, R., Valentim de Brito, K.C., Salmon, D. , Bousbata, S. High-Throughput Identification of the Rhodnius prolixus Midgut Proteome Unravels a Sophisticated Hematophagic Machinery. Proteomes 2020, 8, 16

Tomani, J.C.D. , Kagisha, V. , Tchinda, A.T. , Jansen, O. , Ledoux, A. , Vanhamme, L. , Frederich, M. , Muganga, R. , Souopgui, J. The Inhibition of NLRP3 Inflammasome and IL-6 Production by Hibiscus noldeae Baker f. Derived Constituents Provides a Link to Its Anti-Inflammatory Therapeutic Potentials. Molecules 2020, 25, 4693.


Shey, R.A., Ghogomu, S.M., Shintouo, C.M., Nkemngo, F.N., Nebangwa, D.N., Esoh, K., Yaah, N.E., Manka’aFri, M., Nguve, J.E., Ngwese, R.A., Njume, F.N., Bertha, F.A., Ayong, L., Njemini, R., Vanhamme, L., Souopgui, J. Computational Design and Preliminary Serological Analysis of a Novel Multi-Epitope Vaccine Candidate against Onchocerciasis and Related Filarial Diseases. Pathogens 2021, 10, 99. https://doi.org/10.3390/pathogens10020099

Bougarne N, Mylka V, Ratman D, Beck IM, Thommis J, De Cauwer L, Tavernier J, Staels B, Libert C, De Bosscher K. Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses. Front Immunol. 2019 Aug 9 ;10:1769. doi : 10.3389/fimmu.2019.01769. PMID : 31447832 ; PMCID : PMC6695567.

Tomani, J.C.D. ; Bonnet, O. ; Nyirimigabo, A. ; Descham s,W. ; Tchinda, A.T. ; Jansen, O. ; Ledoux, A. ; Mukazayire, M.J. ; Vanhamme, L. ; Frédérich, M. ; Muganga, R. and Souopgui, J. In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of Eriosema montanum Baker f. (Fabaceae). Molecules 2021, 26, 2795. https://doi.org/10.3390/molecules26092795
Ouali R, Vieira LR, Salmon D, Bousbata S. Early Post-Prandial Regulation of Protein Expression in the Midgut of Chagas Disease Vector Rhodnius prolixus Highlights New Potential Targets for Vector Control Strategy. Microorganisms. 2021 Apr 11 ;9(4):804. doi : 10.3390/microorganisms9040804.


Yengo, B.N. ; Shintouo, C.M. ; Hotterbeekx, A. ; Yaah, N.E. ; Shey, R.A. ; Quanico, J. ; Baggerman, G. ; Ayong, L. ; Vanhamme, L. ; Njemini, R. ; et al. Immunoinformatics Design and Assessment of a Multiepitope Antigen (OvMCBL02) for Onchocerciasis Diagnosis and Monitoring. Diagnostics 2022, 12, 1440. https://doi.org/10.3390/diagnostics12061440